Peptides have become pivotal in modern weight loss and metabolic health treatments. Semaglutide, Tirzepatide, Retatrutide, and Cagrisema are among the leading options in this field, each offering unique benefits and mechanisms of action. For individuals seeking effective and cost-efficient solutions, understanding how these peptides compare in effectiveness, pricing, and treatment duration is essential.
Comparison of Effectiveness
Peptide | Mechanism of Action | Average Weight Loss |
---|---|---|
Semaglutide | GLP-1 receptor agonist | Up to 15% |
Tirzepatide | GLP-1 and GIP receptor dual agonist | Up to 20% |
Retatrutide | GLP-1, GIP, and glucagon receptor agonist | Up to 25% (preliminary data) |
Cagrisema | 50/50 Cagrilintide and Semaglutide Blend | Up to 27% |
Key Insights
- ✨ Semaglutide: Effective for weight loss and widely studied, with a tolerable safety profile.
- 💡 Tirzepatide: Superior weight loss outcomes due to its dual-action mechanism.
- 🌟 Retatrutide: Early data shows exceptional results, making it a promising contender.
- 🔗 Cagrisema: Combines the strengths of two peptides for a highly effective solution.
Monthly Supply Costs and Treatment Duration
The costs below are based on the average weekly dosages, peptide prices per vial, and a typical treatment duration of 6 months:
Peptide | Weekly Dose (mg) | Vial Size (mg) | Price per Vial | Monthly Cost | Treatment Duration (Months) | Total Cost | Total Costs / Average Weight Loss |
---|---|---|---|---|---|---|---|
Semaglutide | 1.5 mg | 5 mg | €100.00 | €120.00 | 6 | €720.00 | €48.00 per 1% weight loss |
Tirzepatide | 7.5 mg | 10 mg | €180.00 | €540.00 | 6 | €3,240.00 | €162.00 per 1% weight loss |
Retatrutide | 5 mg | 10 mg | €300.00 | €600.00 | 6 | €3,600.00 | €144.00 per 1% weight loss |
Cagrisema | 1.5 mg | 10 mg | €320.00 | €192.00 | 6 | €1,152.00 | €46.08 per 1% weight loss |
Cost Analysis
- 💰 Semaglutide: The most cost-effective option for budget-conscious users, with a total treatment cost of €720.00 and a ratio of €48.00 per % weight loss.
- 📈 Tirzepatide: Higher dosage requirements significantly increase the total treatment cost to €3,240.00, with a higher ratio of €162.00 per % weight loss.
- 🛠️ Retatrutide: Premium-priced peptide with cutting-edge mechanisms, resulting in a total cost of €3,600.00 and a ratio of €144.00 per % weight loss.
- ⚖️ Cagrisema: Balanced cost considering its dual-therapy benefits, with a total cost of €1,152.00 and the best ratio of €46.08 per % weight loss.

Key Takeaways
- 📊 Effectiveness: Retatrutide and Cagrisema lead in potency, while Semaglutide and Tirzepatide remain effective and well-researched options.
- 🏷️ Cost Efficiency: Semaglutide offers the best value for cost-sensitive individuals. Cagrisema provides advanced benefits at a moderate increase in cost.
- 🕒 Treatment Duration: All peptides show significant results over an average treatment duration of 6 months, with total costs varying based on dosage and price per milligram.
- ⚖️ Value Ratio: Cagrisema delivers the best total cost to weight loss ratio, making it a compelling choice for cost-effectiveness.
Conclusion
When it comes to weight loss and metabolic health, ✨ Cagrisema emerges as the most powerful and cost-effective treatment. Its combination of Cagrilintide and Semaglutide delivers unparalleled potency with the best value for weight loss results. While other peptides like 💡 Tirzepatide, 🌟 Retatrutide, and ✨ Semaglutide provide significant benefits, ⚖️ Cagrisema strikes the optimal balance between effectiveness and affordability, making it a standout choice. Consulting a healthcare professional is essential for determining the best course of treatment tailored to your needs.